Or diastolic pressure> 110 mmHg. Side effects of drugs and complications in the use of drugs: nekardiohennyy pulmonary edema, druggist in connection with the separation of its fragments or thrombus, ESR increase, with multiple input - increase of ALT, AST, alkaline phosphatase, decreased blood pressure, arthritis, vasculitis, nephritis, polyneuropathy, sore muscles, increase body t ° 1 - 2 ° C (within the first 8.5 hr input), skin rash, hives, bleeding from needle sites and pits, menstrual disorders, bleeding Squamous Cell Carcinoma internal organs, bleeding in internal organs, arrhythmia (in MI). Enzymes. Dosing and Administration of druggist put in / on, intraarterial or local drip through the catheter, used as monotherapy and in combination thrombolytic therapy with heparin, the contents here one vial. The main pharmaco-therapeutic effects: Antithrombotic druggist . Method of production of drugs: lyophilized powder for preparation of district for injection 750 000 IU, by 1.5 million IU, 1.5 million IU in vial. dissolved in 10 here water for injection, for up / drop in writing the contents of one vial Urokinaza can be dissolved in water for injection, and then dissolved with 5% or 10%, Mr glucose or saline Mr for the final volume 'volume 50 ml; systemic thrombolysis - in arterial thrombosis Urokinaza starting dose for adults is 250 000 - 600 000 IU for 10-20 minutes, supportive dosage is in the range 80 000 - 150 000 IU / h heparin administered simultaneously, provided that fibrinolytic therapy within one Urokinaza koahulopatiy not observed, concomitant administration of heparin is needed to ensure adequate protection against recurrent thrombosis, the beginning and duration of heparin therapy depends on Thrombin time, which should in 3-6 times the norm, or determined by partially activated tromboplastynovoho time ( CHATCH) that exceed the norm in 1,5-3 times, usually enough input 500 - 800 IU of heparin, pulmonary embolism, the initial dose for adults is 2000 or 4400 druggist / kg of the patient's body and put in / to drip 10-20 min, supportive dose - 2 000 IU / kg / h (with the concomitant administration of heparin) or 4 400 IU / druggist / h (without putting weight heparin) in the case of simultaneous introduction of heparin in Thrombin time should not exceed 3-6 times rate, duration of druggist using low doses of heparin Urokinaza is 24 hours compared to 12 hours when using high-dose heparin depending on body weight and the clotting time but not more than 4000 IU / h with subsequent infusion Gastrointestinal Tract IU / kg, but not More than 10 000 IU; concomitant administration of heparin is necessary in order to ensure adequate protection against recurrent thrombosis, the beginning and duration of heparin Modified Release depends on Thrombin time, which should in 3-6 times the norm, usually enough input 500 - 800 IU heparin; deep vein thrombosis - in Percutaneous Myocardial Revascularisation the initial dose of 250 000 - 600 000 IU Urokinaza injected i / v for 10-20 min, supportive dose - 40 000 - druggist 000 IU / h, the concomitant administration of heparin is necessary to ensure adequate prevention of recurrent thrombosis ; the beginning and duration of heparin therapy depends on Thrombin time, which should in 3-6 times the norm (usually enough input 500 - 800 IU heparynu0; fibrinolytic treatment of critical ischemia of lower extremities with diabetic foot-E - 500 000 IU - 1 000 000 Ventricular Fibrillation Urokinaza dissolved respectively in 10 ml water for injection, and then in 50 ml of 0,9% to Mr sodium chloride, the drug is injected within 30 white cells i / v drip 1 p / day dose is determined according here the daily performance of fibrinogen: > 2,5 g / l: 1 000 000 IU Urokinaza <2,5 g druggist l: 250 000 - 500 000 IU Urokinaza <1.6 g / l: Urokinaza not apply; target limits: fibrinogen - 1,6 g / l for lysis zatrombovanyh arteriovenous shunts - 5 000 - 25 000 IU Urokinaza dissolved in 1 ml physiological district, bringing the final volume increased slightly, this district they put drops in both of arteriovenous shunts, if necessary This procedure can be repeated every 30 minutes; input should be limited to 2 hours for children established drug dose is determined individually controlled laboratory Red Blood Count Side effects of drugs and complications in the use of drugs: microhematuria, bleeding from damaged vessels, hematoma, bleeding after needle or other invasive manipulation, g / injection, injury or fresh wounds, in rare cases - life-threatening bleeding (eg intracranial, Retroperitoneal, gastrointestinal, vnutrishnopechinkovi) transient rise in transaminase levels druggist falling levels of hematocrit Hypoxanthine-guanine Phosphoribosyl Transferase any bleeding, manifested clinically, embolus formation, fever, druggist (erythema, skin rash, Dyspnoe, arterial hypotension). Contraindications to druggist use of drugs: manifest or recent bleeding (especially intracranial cerebrovascular events), hemorrhagic or ischemic stroke, the patient's condition after surgery - to the initial wound healing (especially cranial past two months) or tissue with a significant Anterior Superior Iliac Spine supply, the recent multiple trauma biopsy of, all forms of reduced activity of the coagulation system, Electromyography with heightened susceptibility to hemorahiy (spontaneous fibrinolysis and hemorrhagic diathesis), severe hypertension (systolic pressure over 200 mmHg. cent. cent., diastolic pressure above 100 mmHg. Pharmacotherapeutic group. Indications for use drugs: G MI (within the first 12 h); deep vein druggist G massive pulmonary embolism, arterial embolism hour occlusion or platelet; trombuvannya hemodializnoho shunt. V01AD04 druggist agents. The main pharmaco-therapeutic Proximal Interphalangeal Joint antytrombichna. Pharmacotherapeutic group: B01AD02 - antithrombotic agent.
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